Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats.

摘要: Nitrosoamines such as N-nitrosodiethylamine (NDEA) produce oxidative stress due to generation of reactive oxygen species and may alter antioxidant defence system in the tissues. NDEA was administered ip a single dose rats LD50 or lower amounts animals were sacrificed after 0-48 hr treatment. The results showed that lipid peroxidation liver increased, however no significant increase kidney LPO observed administration. Superoxide dismutase (SOD) glutathione reductase (GSH-R) activity increased liver, however, catalase (CAT) inhibited treated rats. Kidney an SOD initial decrease along with GSH-R However, CAT not significantly altered intoxicated Serum transaminases, serum alkaline phosphatase blood urea nitrogen, creatinine scrum proteins elevated indicate NDEA-induced alteration enzymes neutralise stress.