Eager for better migraine therapies: keep your (telcage)PANTs on.

摘要: Pharmacologic therapies for migraine have traditionally been divided into 2 broad and distinct categories.1– 3 Acute treatments are given at the time of a attack to relieve pain restore function. Preventive usually taken on daily basis reduce frequency headaches. Conventional wisdom suggests that drugs used as acute (i.e., triptans, ergot alkaloids, nonsteroidal anti-inflammatory agents) differ from preventive (antiepilepsy drugs, β-blockers, calcium channel blockers, antidepressants) in mechanism action, pharmacokinetic profiles, patterns use. Some treatments, particularly opioids barbiturates, if too often, might lead worsening headaches process variously conceptualized transformation, chronification, or development medication overuse headache.4