Techniques for long-term multisite neuronal ensemble recordings in behaving animals.

摘要: Advances in our understanding of neural systems will go hand with improvements the experimental techniques used to study these systems. This article describes a series methodological developments aimed at enhancing power methods needed record simultaneously from populations neurons over broad regions brain awake, behaving animals. First, laboratory has made many advances electrode design, including movable bundle and array electrodes smaller assemblies. Second, perform longer more complex multielectrode implantation surgeries primates, we have modified surgical procedures by employing comprehensive physiological monitoring akin human neuroanesthesia. We also developed minimizing tissue damage facilitating penetration cortical surface. Third, integrated new technologies into ensemble, stimulus behavioral recording experiments provide detailed measurements variables. Finally, data analytical are being analyze increasingly large quantities data.