Intestinal microbiota promote enteric virus replication and systemic pathogenesis.

摘要: Intestinal bacteria aid host health and limit bacterial pathogen colonization. However, the influence of on enteric viruses is largely unknown. We depleted intestinal microbiota mice with antibiotics before inoculation poliovirus, an virus. Antibiotic-treated were less susceptible to poliovirus disease supported minimal viral replication in intestine. Exposure or their N-acetylglucosamine-containing surface polysaccharides, including lipopolysaccharide peptidoglycan, enhanced infectivity. found that binds lipopolysaccharide, exposure cell association infection. The pathogenesis reovirus, unrelated virus, also was more severe presence microbes. These results suggest antibiotic-mediated depletion diminishes virus infection exploit microbes for transmission.