Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea
作者： Khang D.H. Nguyen , Phu H. Dang , Hai X. Nguyen , Mai T.T. Nguyen , Suresh Awale
DOI: 10.1016/J.BMCL.2017.04.087
关键词:
摘要: A new lignan, 9'-methoxypinoresinol (1), and two glycosylated 5-hydroxymethylfurfurals, calofurfuralside (2), B (3), together with nine known compounds (4-12) have been isolated from the active fractions, CHCl3 (IC50, 0.32μgmL-1) EtOAc 0.55μgmL-1) fractions of leaves Calotropis gigantea. Their structures were elucidated based on NMR MS data. Among compounds, 1 9 exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cell line under normoglycemic condition IC50 values 3.7 3.3μM, respectively. 9'-Methoxypinoresinol (1) significantly inhibited colony formation cells in a concentration-dependent manner.
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sci-hub.se 参考文章(21)
Hirotaka SHIBUYA, Ru-song ZHANG, Jong Dae PARK, Nam In BAEK, Yasuyuki TAKEDA, Masayuki YOSHIKAWA, Isao KITAGAWA, Indonesian Medicinal Plants. V. Chemical Structures of Calotroposides C, D, E, F, and G, Five Additional New Oxypregnane-Oligoglycosides from the Root of Calotropis gigantea (Asclepiadaceae) Chemical & Pharmaceutical Bulletin. ,vol. 40, pp. 2647- 2653 ,(1992) , 10.1248/CPB.40.2647
Hai Xuan Nguyen, Mai Thanh Thi Nguyen, Thy Anh Nguyen, Nhi Y Thi Nguyen, Dao Anh Thi Phan, Phuoc Ho Thi, Trong Huu Phan Nguyen, Phu Hoang Dang, Nhan Trung Nguyen, Jun-ya Ueda, Suresh Awale, Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line. Fitoterapia. ,vol. 91, pp. 148- 153 ,(2013) , 10.1016/J.FITOTE.2013.08.018
Sowmiah Subbiah, Svilen P. Simeonov, José M. S. S. Esperança, Luís Paulo N. Rebelo, Carlos A. M. Afonso, Direct transformation of 5-hydroxymethylfurfural to the building blocks 2,5-dihydroxymethylfurfural (DHMF) and 5-hydroxymethyl furanoic acid (HMFA) via Cannizzaro reaction Green Chemistry. ,vol. 15, pp. 2849- 2853 ,(2013) , 10.1039/C3GC40930A
Supawadee Parhira, Zi-Feng Yang, Guo-Yuan Zhu, Qiao-Lian Chen, Bei-Xian Zhou, Yu-Tao Wang, Liang Liu, Li-Ping Bai, Zhi-Hong Jiang, In Vitro Anti-Influenza Virus Activities of a New Lignan Glycoside from the Latex of Calotropis gigantea PLoS ONE. ,vol. 9, pp. e104544- ,(2014) , 10.1371/JOURNAL.PONE.0104544
Yueh-Hsiung Kuo, Ming-An Ouyang, Yung-Shung Wein, Zhen-Kun Zhang, Inhibitory activity against tobacco mosaic virus (TMV) replication of pinoresinol and syringaresinol lignans and their glycosides from the root of Rhus javanica var. roxburghiana. Journal of Agricultural and Food Chemistry. ,vol. 55, pp. 6460- 6465 ,(2007) , 10.1021/JF0709808
Malte Brasholz, Hans-Ulrich Reißig, Alkoxyallene‐Based De Novo Synthesis of Rare Deoxy Sugars: New Routes to L‐Cymarose, L‐Sarmentose, L‐Diginose and L‐Oleandrose European Journal of Organic Chemistry. ,vol. 2009, pp. 3595- 3604 ,(2009) , 10.1002/EJOC.200900450
Ki Hyun Kim, Eunjung Moon, Sang Un Choi, Sun Yeou Kim, Kang Ro Lee, Biological evaluation of phenolic constituents from the trunk of Berberis koreana. Bioorganic & Medicinal Chemistry Letters. ,vol. 21, pp. 2270- 2273 ,(2011) , 10.1016/J.BMCL.2011.02.104
Adriana C. Casabuono, Alicia B. Pomillo, Lignans and a stilbene from Festuca argentina Phytochemistry. ,vol. 35, pp. 479- 483 ,(1994) , 10.1016/S0031-9422(00)94786-1
Madhuri Kadiyala, S. Ponnusankar, Kannan Elango, Calotropis gigantiea (L.) R. Br (Apocynaceae): A phytochemical and pharmacological review Journal of Ethnopharmacology. ,vol. 150, pp. 32- 50 ,(2013) , 10.1016/J.JEP.2013.08.045
Namki Cho, Heejung Yang, Jung Wha Kim, Young Choong Kim, Sang Hyun Sung, Chemical constituents isolated from Disporum viridescens leaves and their inhibitory effect on nitric oxide production in BV2 microglial cells Bioorganic & Medicinal Chemistry Letters. ,vol. 24, pp. 5675- 5678 ,(2014) , 10.1016/J.BMCL.2014.10.068