Inflammatory bowel disease-associated colorectal cancer: proctocolectomy and mucosectomy do not necessarily eliminate pouch-related cancer incidences
作者： Amosy E. M’Koma , Harold L. Moses , Samuel E. Adunyah
DOI: 10.1007/S00384-011-1137-4
关键词:
摘要: Background Colorectal cancer (CRC), the most lethal long-term complication of inflammatory bowel disease (IBD), is culmination a complex sequence molecular and histologic derangements colon epithelium that are initiated at least partially sustained by prolonged chronic inflammation. Dysplasia, earliest manifestation this process, plays an important role in prevention providing first clinical alert under way serving as endpoint colonoscopic surveillance patients high risk for CRC. Restorative proctocolectomy (RPC) indicated with IBD, specifically ulcerative colitis refractory to medical treatment, emergency conditions, and/or case neoplastic transformation. Even after RPC mucosectomy, pouch-related carcinomas have recently been reported increasing frequency since report 1984. We review IBD-associated CRC neoplasia prevalence, adverse events, factors, surveillances.
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