Changes in plasma lipid and lipoprotein cholesterol and weight prior to the diagnosis of cancer

摘要: Changes in lipoprotein cholesterol, total plasma and weight prior to the diagnosis of cancer were examined 103 men who developed a cohort 3805 type IIa hyperlipidemic aged 35–59 enrolled Lipid Research Clinics Coronary Primary Prevention Trial. Study measurements made bimonthly. After adjusting for effects trial intervention other determinants lipid levels, cholesterol levels cases diagnosed with nonlocalized dropped below expected level approaching when compared entire study population. The decrease averaged 9.3 mg/dl began about 2 years diagnosis. Weight an average 1.2 kg over same period. significantly lower than within 8 months ( P < 0.05). No was seen those localized malignancies. Patterns low-density reflected cholesterol. There no clear relationship between patterns change triglycerides high-density In future, investigations any host physiological state occurrence should account metabolic preclinical disease demonstrated here. To protect against spurious conclusions, incident occurring measurement be analyzed separately. studies mortality, deaths 3.5 base-line