Serum nesfatin-1 is associated with testosterone and the severity of erectile dysfunction.

作者: Wei Sun , Liang‐Kuan Bi , Dong‐Dong Xie , De‐Xin Yu

DOI: 10.1111/AND.13634

关键词:

摘要: This cross-sectional study aimed to evaluate serum nesfatin-1 concentrations in patients with erectile dysfunction (ED). Patients ED were selected from the Department of Urology Second Affiliated Hospital Anhui Medical University. The International Index Erectile Function-5 (IIEF-5) was used severity ED. Serum and gonadal hormone levels, including luteinising (LH), follicle-stimulating (FSH) testosterone measured. IIEF-5 scores (t = -21.034, p < .001) levels -7.043, significantly lower than healthy controls. Moreover, showed decreased -3.478, .001), whereas there no significant differences FSH -0.088, .930) LH 1.114, .270) between two groups. Furthermore, positive relationships found (r .742, .395, .009) patients. Additionally, based on receiver operating characteristic curve analysis, area under for 0.884 83.3% sensitivity 81.4% specificity discriminating decrease level may be related

参考文章(42)
Ernst R. Schwarz, Vishal Kapur, The relationship between erectile dysfunction and cardiovascular disease. Part I: pathophysiology and mechanisms. Reviews in Cardiovascular Medicine. ,vol. 8, pp. 214- 219 ,(2007)
Michael Blute, Payam Hakimian, James Kashanian, Alex Shteynshluyger, Michael Lee, Ridwan Shabsigh, Erectile dysfunction and testosterone deficiency. Frontiers of Hormone Research. ,vol. 37, pp. 108- 122 ,(2009) , 10.1159/000176048
Zekiye Catak, Suleyman Aydin, İbrahim Sahin, Tuncay Kuloglu, Aziz Aksoy, Adile Ferda Dagli, Regulatory neuropeptides (ghrelin, obestatin and nesfatin-1) levels in serum and reproductive tissues of female and male rats with fructose-induced metabolic syndrome. Neuropeptides. ,vol. 48, pp. 167- 177 ,(2014) , 10.1016/J.NPEP.2014.04.002
G Çatlı, A Anık, T Küme, ÖG Çalan, BN Dündar, E Böber, A Abacı, None, Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche. Journal of Endocrinological Investigation. ,vol. 38, pp. 909- 913 ,(2015) , 10.1007/S40618-015-0277-8
Lucia L. Senin, Omar Al-Massadi, Silvia Barja-Fernandez, Cintia Folgueira, Cecilia Castelao, Sulay A. Tovar, Rosaura Leis, Francisca Lago, Javier Baltar, Ivan Baamonde, Carlos Dieguez, Felipe F. Casanueva, Luisa M. Seoane, Regulation of NUCB2/nesfatin-1 production in rat's stomach and adipose tissue is dependent on age, testosterone levels and lactating status. Molecular and Cellular Endocrinology. ,vol. 411, pp. 105- 112 ,(2015) , 10.1016/J.MCE.2015.04.016
Vincenzo Mirone, Ciro Imbimbo, Angela Bortolotti, Elisabetta Di Cintio, Enrico Colli, Marina Landoni, Maurizio Lavezzari, Fabio Parazzini, Cigarette Smoking as Risk Factor for Erectile Dysfunction: Results from An Italian Epidemiological Study European Urology. ,vol. 41, pp. 294- 297 ,(2002) , 10.1016/S0302-2838(02)00005-2
Jinhee Kim, Hyunwon Yang, Nesfatin-1 as a New Potent Regulator in Reproductive System Development & reproduction. ,vol. 16, pp. 253- 264 ,(2012) , 10.12717/DR.2012.16.4.253
Varant Kupelian, Ridwan Shabsigh, Thomas G. Travison, Stephanie T. Page, Andre B. Araujo, John B. McKinlay, Is There a Relationship Between Sex Hormones and Erectile Dysfunction? Results From the Massachusetts Male Aging Study The Journal of Urology. ,vol. 176, pp. 2584- 2588 ,(2006) , 10.1016/J.JURO.2006.08.020