Is routine influenza immunization warranted in early pregnancy
作者： Danuta M. Skowronski , Gaston De Serres
DOI: 10.1016/J.VACCINE.2009.03.079
关键词:
摘要: Abstract Routine influenza immunization is recommended for select groups because of their higher risk serious outcomes. Based on that benefit–risk framework, we assessed whether routine administration trivalent inactivated vaccine (TIV) warranted in pregnancy, beginning 1st trimester. Higher maternal mortality due to was extensively described during the 1918 and 1957 pandemics, but epidemiologic evidence thereafter limited case reports a single ecologic analysis season. Significantly elevated rates hospitalization have been reported with seasonal trimester among women comorbidities 2nd half normal pregnancy. TIV protection against outcomes pregnant has not yet shown. Although harm also shown, sample size date insufficient assert safety Benefit–risk suggests may be at any stage pregnancy certain pandemics annually comorbidities. protect influenza-related Evidence otherwise recommend as standard practice all healthy early
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