Chapter 4 – Nitric Oxide and Cellular Stress Response in Brain Aging and Neurodegenerative Disorders
作者： Vittorio Calabrese , Cesare Mancuso , Carlo De Marco , Anna Maria Giuffrida Stella , D. Allan Butterfield
DOI: 10.1016/B978-044452809-4/50145-9
关键词:
摘要: The term “nitrosative stress” is used to indicate the cellular damage elicited by reactive nitrogen species (RNS), including nitric oxide (NO) and its congeners peroxynitrite (OONO − ), N 2 O 3 , nitroxyl anion, nitrosonium. Nitrosative stress has been implicated in pathogenesis of neurodegenerative disorders. In this chapter, importance nitrosative brain aging disorders as well key role played HO-1 modulating onset progression Alzheimer's disease (AD) Parkinson's (PD) discussed. mechanism(s) which involved diseases manifold. fact, NO itself shown regulate selected proteins—such parkin, metalloproteinase-9 (MMP-9), glyceraldehyde-3-phosphate dehydrogenase (GADPH) —via an S -nitrosylation reaction, thereby triggering PD other On hand, can react with oxygen (ROS), particular superoxide, derived from mitochondrial impairment form peroxynitrite, nitrosates proteins forms 3-NT-modified proteins, cause metabolic pathways therefore cell death. Therefore, it possible hypothesize that drugs are able counteract iNOS induction excess formation be very useful limiting consequences oxidative associated Furthermore, compelling evidence vitagene network a defense system operating during times opens new perspectives treatment diseases.
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