Non-Invasive Technology That Improves Cardiac Function after Experimental Myocardial Infarction: Whole Body Periodic Acceleration (pGz)

摘要: Myocardial infarction (MI) may produce significant inflammatory changes and adverse ventricular remodeling leading to heart failure premature death. Pharmacologic, stem cell transplantation, exercise have not halted the inexorable rise in prevalence great economic costs of despite extensive investigations such treatments. New therapeutic modalities are needed. Whole Body Periodic Acceleration (pGz) is a non-invasive technology that increases pulsatile shear stress endothelium thereby producing several beneficial cardiovascular effects as demonstrated animal models, normal humans patients with disease. pGz upregulates endothelial derived nitric oxide synthase (eNOS) its phosphorylation (p-eNOS) improve myocardial function models stunning preconditioning. Here we test whether applied chronically after focal rats improves functional outcomes from MI. Focal MI was produced by left coronary artery ligation. One day ligation animals were randomized receive daily treatments for four weeks (MI-pGz) or serve controls (MI-CONT), an additional group non-infarction (Sham). Echocardiograms invasive pressure volume loop analysis carried out. Infarct transmurality, fibrosis, markers anti-inflammatory cytokines determined along protein eNOS, p-eNOS inducible (iNOS).At weeks, survival 80% MI-pGz vs 50% MI-CONT (p< 0.01). Ejection fraction fractional shortening relation indices afterload contractility significantly better MI-pGz. The latter where associated decreased infarct transmurality fibrosis increased p-eNOS. Additionally, had lower levels iNOS, (IL-6, TNF-α), higher level cytokine (IL-10). improved contractile performance, remodeling. simple, safe, modality