Modified RECIST criteria for assessment of response in malignant pleural mesothelioma

摘要: Background: The growth pattern of malignant pleural mesothelioma makes the use RECIST (response evaluation criteria in solid tumours) response difficult. We have developed and validated Modified adapted to mesothelioma. Patients methods: evaluated 73 patients from two clinical trials cisplatin/gemcitabine chemotherapy Tumour thickness perpendicular chest wall or mediastinum was measured positions at three separate levels on thoracic CT scans. sum six measurements defined a unidimensional measure. Bidimensionally measureable lesions were unidimensionally as for RECISI. All added obtain total tumour measurement. A reduction least 30% occasions 4 weeks apart partial response; an increase 20% over nadir measurement, progressive disease. validity modified gauged by evaluating survival pulmonary function. Results: Response according these predicted superior (15.1 versus 8.9 months; P = 0.03) forced vital capacity (FVC) during treatment (P <0.0001). significant correlation between change linear measurement FVC seen (R 0.63; 0.0001). Conclusion: These correlate with lung function can be used measure outcome