Brain drug delivery of small molecules using immunoliposomes
作者： J. Huwyler , D. Wu , W. M. Pardridge
关键词:
摘要: Immunoliposomes (antibody-directed liposomes) were used in the present study for delivery of the antineoplastic agent daunomycin to the rat brain. A coupling procedure was introduced, which allows conjugation of a thiolated antibody to maleimide-grafted 85-nm liposomes sterically stabilized with PEG. Antibody was thereby coupled to the terminal end of a PEG-conjugated linker lipid. No brain uptake of PEG-conjugated liposomes carrying [3H] daunomycin was observed. However, brain targeting of immunoliposomes carrying [3H] …
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