Genomic basis of aging and life-history evolution in Drosophila melanogaster.

摘要: Natural diversity in aging and other life-history patterns is a hallmark of organismal variation. Related species, populations, individuals within populations show genetically based variation life span aspects age-related performance. Population differences are especially informative because these can be large relative to within-population they occur organisms with otherwise similar genomes. We used experimental evolution produce divergent for late-age fertility then deep genome sequencing detect sequence variants nucleotide-level resolution. Several genes regions showed strong signatures selection, the same were implicated independent comparisons, suggesting that alleles selected replicate lines. Genes related oogenesis, immunity, protein degradation as important modifiers late-life Expression profiling functional annotation narrowed list candidate 38, most which novel candidates regulating aging. Life early age fecundity negatively correlated among populations; therefore, we identified also regulators major trade-off. More generally, argue hitchhiking mapping powerful tool uncovering molecular bases quantitative genetic