Safety of intravenous iron formulations: facts and folklore.

摘要: It is unlikely that anyone reading this review was not taught intravenous (IV) iron dangerous. While early preparations were associated with an unacceptably high rate of serious adverse events, most notably anaphylactic shock, newer formulations carbohydrate shells which bind the elemental more tightly, allowing for a much slower release, are very safer toxicity being marginal to absent in prospective trials. The perception risk fueled by misinterpretation and misinformation clinical nature minor infusion reactions1, inappropriate use premedication diphenhydramine2 inferences made about relative safety available using spontaneous event reporting systems, methodologies proscribed regulatory agencies3,4. In article we published evidence on different formulations, highlight errors interpretation intervention when reactions occur, posit paradigm maximising underutilised therapeutic tool.