The effects of early exposure to MK-801 during environmental enrichment on spatial memory, methamphetamine self-administration and cue-induced renewal in rats.

摘要: Abstract Objective Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect EE has also been examined in field methamphetamine (METH) dependence. present study was designed to examine whether cognitive alterations by dizocilpine (MK-801) adolescence can impact on spatial memory, METH self-administration (SA), cue-induced renewal adulthood. Methods In Experiments 1 2, Morris Water Maze (MWM) performance, c-Fos expression N-methyl d -aspartate receptor subtype 2B (NMDAR2B) levels were determined various brain regions following a change rearing condition from isolation environment (IE) at different points (PD 41–60 or PD 51–70). 3 4, MWM performance SA behaviors adulthood tested adolescent administration MK-801 during periods 51–70) under conditions. Results IE significantly decreased as compared exposure 51–70. Different conditions altered NMDA2B activity regionally specific pattern. induced structural systemic changes hippocampus that associated with improvements memory. Early 51–70 produced distinctive effects behavioral outcomes renewal. Conclusion have profound memory