Effects of calcium on the migration and recruitment of macrophages and macrophage-derived foam cells.

摘要: Calcium is thought to play an important role in the genesis of atherosclerotic lesions, but precise mechanisms involved are unclear. In present investigation, we have used vitro systems investigate effects calcium on one key aspect lesion development: migration macrophages and macrophage/foam cells. Using agarose plate assays, migratory characteristics exposed 1) no lipoprotein, 2) low density lipoprotein (LDL), 3) acetylated (acLDL), ) oxidized were examined. The most marked stimulatory effect macrophage mobility was observed when freshly isolated cells acLDL during assay. High levels exogenous found suppress migration. As responses a uniform concentration agents surrounding medium may differ from chemotactic gradient, ma...