CHAPTER 221 – Phosphorylation of G Proteins

摘要: This chapter presents a review on what is known about G-protein phosphoryation and its subsequent effects function. In normal cells, heterotrimeric subunits are to undergo several forms of co-translational or post-translational modification. Lipid modifications, including N-myristoylation palmitoylation Gα prenylation Gγ subunits, required for plasma membrane targeting contribute the interaction with Gβγ effectors, regulators signaling (RGS proteins). members each four major families (Gαs, Gαi, Gαq, Gα12), also phosphorylation serine tyrosine residues. addition, one subunit phosphorylated. reviews There convincing evidence that substrates and/or in vitro some cases, vivo. The functional relevance these events less well established. Serine Ga by second messenger-dependent protein kinases potential mechanism feedback regulation G-protein-coupled receptor signaling. Tyrosine may provide cross-talk between non-receptor G-protein-dependent pathways