Oxygenated Carotenoid Lutein and Progression of Early Atherosclerosis The Los Angeles Atherosclerosis Study
作者： James H. Dwyer , Mohamad Navab , Kathleen M. Dwyer , Kholood Hassan , Ping Sun
DOI: 10.1161/01.CIR.103.24.2922
关键词:
摘要: Background—Carotenoids are hypothesized to explain some of the protective effects fruit and vegetable intake on risk cardiovascular disease. The present study assessed oxygenated carotenoid lutein against early atherosclerosis. Methods Results—Epidemiology: Progression intima-media thickness (IMT) common carotid arteries over 18 months was determined ultrasonographically related plasma among a randomly sampled cohort utility employees age 40 60 years (n=480). Coculture: impact monocyte response artery wall cell modification LDL in vitro by quantification migration coculture model human intima. Mouse models: supplementation atherosclerotic lesion formation vivo assigning apoE-null mice chow or plus (0.2% weight) receptor–null Western diet lutein. IMT progression declined with increa...
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