[The application of 4-aminopyridine in calcium channel inhibitors acute poisoning].

摘要: Calcium channel inhibitors have been extensively used to treat arterial hypertension, ischaemic heart disease and supraventricular rhythm irregularities. The poisonings by that category of drugs are extremely dangerous, particularly when accompanied intoxication with other affecting the circulatory function. This paper reports 3 cases calcium (verapamil diltiazem) in combination angiotensin convertase nonselective beta-adrenolytics. Circulatory insufficiency cardiac abnormalities were noted all reported cases, one form ventricular bigeminy two episodes fibrillation, while 1 degree atrioventricular block. persisting hypotonia combined disturbances could not be prevented typical conservative treatment involving intravenous administration infusion fluids, formulations, catecholamines atropin. application 4-amino-pyridine (Pymadin) caused tension rate higher, disappeared. suggest a beneficial effect 4-aminopyridine inhibitors; however, up present time, no detailed procedures determined for like those above. has included list antidotes approved WHO and, therefore, broader tests more clinical observations required confirm its therapeutic value.