Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway

摘要: Accumulating evidence demonstrates that Macleaya cordata extract exerts antiviral and anti-inflammatory effects in various diseases. The present study aimed to investigate the potential of M. on rotavirus SA11-induced diarrhea mice. Diarrhea severity, levels inflammatory cytokines, histological changes small intestine underlying mechanisms were evaluated rotavirus-stimulated mice treated with 1, 2 4 mg/kg/day or ribavirin (positive control). treatment effectively ameliorated rotavirus-induced a dose-dependent manner by decreasing viral RNA levels. In addition, reduced release pro-inflammatory cytokines including migration inhibitory factor, interleukin (IL)-8, IL-β, interferon-γ tumor necrosis factor-α, elevated secretion cytokine IL-10 following infection. inhibited intestinal epithelial cell apoptosis improved inflammation after also revealed exerted suppressing Janus kinase (JAK2)/STAT3 pathway, as reflected decreased protein expression phosphorylated (p)-JAK2 p-STAT3. Overall, caused rotavirus, which was closely associated suppression JAK2/STAT3 phosphorylation. These data suggested may be applied for diarrhea.