Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease.
作者： Friederike Cordes , Dirk Foell , John Nik Ding , Georg Varga , Dominik Bettenworth
关键词:
摘要: In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for treatment of ulcerative colitis (UC). Although has proven efficacious in patients with active UC, it failed Crohn's disease (CD). This finding strongly hints at a different contribution JAK signaling both entities. Here, we review current knowledge on interplay between JAK/signal transducer and activator transcription (STAT) pathway inflammatory bowel diseases (IBD). particular, provide detailed overview differences similarities JAK/STAT-signaling UC CD, highlight impact JAK/STAT experimental models summarize published evidence immune cells IBD as well genetic association IBD. Finally, describe novel strategies targeting inhibition CD comment limitations challenges new drug class.
sci-hub.st 参考文章(184)
Qi-Fei Liu, Yi Li, Qi-Hong Zhao, Zheng-Yu Wang, Shuang Hu, Chao-Qun Yang, Kui Ye, Li Li, None, Association of STAT4 rs7574865 polymorphism with susceptibility to inflammatory bowel disease: A systematic review and meta-analysis Clinics and Research in Hepatology and Gastroenterology. ,vol. 39, pp. 627- 636 ,(2015) , 10.1016/J.CLINRE.2015.04.002
Yi Li, Jasper Deuring, Maikel P. Peppelenbosch, Ernst J. Kuipers, Colin de Haar, C. Janneke van der Woude, STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis Molecular Medicine. ,vol. 18, pp. 1412- 1419 ,(2012) , 10.2119/MOLMED.2012.00277
G. Fousteri, T. Jofra, I. Debernardis, S. M. Stanford, A. Laurenzi, N. Bottini, M. Battaglia, The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization. Clinical and Experimental Immunology. ,vol. 178, pp. 178- 189 ,(2014) , 10.1111/CEI.12393
Kiyotaka Ohtani, Yoshikazu Ohtsuka, Tamaki Ikuse, Yosuke Baba, Yoko Yamakawa, Yo Aoyagi, Tohru Fujii, Takahiro Kudo, Satoru Nagata, Toshiaki Shimizu, Increased mucosal expression of GATA-3 and STAT-4 in pediatric ulcerative colitis. Pediatrics International. ,vol. 52, pp. 584- 589 ,(2010) , 10.1111/J.1442-200X.2009.03019.X
Robyn Starr, Tracy A. Willson, Elizabeth M. Viney, Leecia J. L. Murray, John R. Rayner, Brendan J. Jenkins, Thomas J. Gonda, Warren S. Alexander, Donald Metcalf, Nicos A. Nicola, Douglas J. Hilton, A family of cytokine-inducible inhibitors of signalling Nature. ,vol. 387, pp. 917- 921 ,(1997) , 10.1038/43206
Toni Weinhage, Jan Däbritz, Anne Brockhausen, Timo Wirth, Markus Brückner, Michael Belz, Dirk Foell, Georg Varga, Granulocyte Macrophage Colony-Stimulating Factor–Activated CD39+/CD73+ Murine Monocytes Modulate Intestinal Inflammation via Induction of Regulatory T Cells Cellular and molecular gastroenterology and hepatology. ,vol. 1, pp. 433- 449 ,(2015) , 10.1016/J.JCMGH.2015.04.005
Alejandro V. Villarino, Yuka Kanno, John R. Ferdinand, John J. O’Shea, Mechanisms of Jak/STAT Signaling in Immunity and Disease Journal of Immunology. ,vol. 194, pp. 21- 27 ,(2015) , 10.4049/JIMMUNOL.1401867
Michael J. Rosen, Rupesh Chaturvedi, M. Kay Washington, Lindsay A. Kuhnhein, Preston D. Moore, Scott S. Coggeshall, Elizabeth M. McDonough, Jörn-Hendrik Weitkamp, Amar B. Singh, Lori A. Coburn, Christopher S. Williams, Fang Yan, Luc Van Kaer, R. Stokes Peebles, Keith T. Wilson, STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines The Journal of Immunology. ,vol. 190, pp. 1849- 1858 ,(2013) , 10.4049/JIMMUNOL.1201373
Danute Pupjalis, Julia Goetsch, Diane J. Kottas, Volker Gerke, Ursula Rescher, Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling Embo Molecular Medicine. ,vol. 3, pp. 102- 114 ,(2011) , 10.1002/EMMM.201000113
Dan Lu, Liang Liu, Xin Ji, Yanan Gao, Xi Chen, Yu Liu, Yang Liu, Xuyang Zhao, Yan Li, Yunqiao Li, Yan Jin, Yu Zhang, Michael A McNutt, Yuxin Yin, The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation Nature Immunology. ,vol. 16, pp. 1263- 1273 ,(2015) , 10.1038/NI.3278