Superoxide Dismutase-A Genetic Marker in Cardiomyopathies

摘要: Cardiomyopathies are a heterogeneous group of heart muscle disorders responsible for great deal morbidity and mortality. Dilated, hypertrophic restrictive the three major categories cardi- omyopathies. Since reactive oxygen species has been implicated in wide range genetic role antioxidant like superoxide dismutase as scavenger highlighted, present study envisages on identifying specific electromorphic association with cardiomyopathies to de- lineate heterogeneity based alle- les at risk. Phenotyping was carried out 8% PAGE red cell membrane samples following Davies (1964) Beauchamp's (1975) protocols. Blood from 62 dilated cardiomyopathy, 80 cardiomy- opathy 86 healthy individuals were collected CARE Hospitals voluntary blood donor camps, Hyderabad. Significant homozygous SOD A*1 (χ2 = 7.58) alleles cardiomyopathy heterozygous A*2-1 (χ 2 5.89) hyper- trophic observed, resulting sig- nificant deviation allelic frequency cardiomyopa- thy compared control highlighting that carrying 7.588) may be greater risk respectively. Thus marker help predic- tion delineating condition spe- cific influencing endog- enous nitric oxide production energy pathways by altering structure function mem- branes is discussed.