C-Glycosylation in platinum-based agents: a viable strategy to improve cytotoxicity and selectivity

摘要: Novel coordinatively saturated platinum(II) compounds bearing C-linked carbohydrates were synthesized and characterized. The complexes exhibit bipyramidal trigonal geometry with a bidentate nitrogen ligand ethylene in the equatorial plane. axial positions are occupied by halide X D-galactose or D-glucose derivative, linked either via C1 C6. designed for evaluation of biological activity because they combine steady coordinative saturation, beneficial action modular sugar moiety organometallic nature Pt-sugar linkage, which is expected to be stable media, until target reached. newly molecules mixed DMSO/aqueous solvents, able bind DNA vitro exhibited selective cytotoxic on cancer cells through apoptosis activation.