The impact of contact lens wear on ocular surface mucins using a novel clinical fluorescence imaging system
作者： Michael L. Read , Maria Navascues-Cornago , Nancy Keir , Carole Maldonado-Codina , Philip B. Morgan
DOI: 10.1016/J.CLAE.2019.08.004
关键词:
摘要: Abstract Purpose Fluorescein-labelled wheat germ agglutinin (F-WGA) acts as a marker for ocular surface mucins. This clinical study sought to investigate whether the degree of F-WGA fluorescence observed at differed between symptomatic contact lens wearers, asymptomatic wearers and non-contact using novel imaging system. Methods Twenty-five participants (10 10 5 wearers) attended single visit. Photographs cornea, bulbar tarsal conjunctiva were captured following application solution. Results The system high-resolution images surface. regions (p Conclusion use mucins allows an improved understanding their distribution across Contact wear appears negatively impact mucin density surface, with most marked effect on cornea. appeared diminished in lid wiper region wearing group, indicating that mechanical interaction this may play role aetiology discomfort. Given ability disclose it is likely be key tool furthering our (i) related discomfort, (ii) designs/materials minimise (iii) dry eye disease other diseases.
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