Corneal Nerve Fractal Dimension: A Novel Corneal Nerve Metric for the Diagnosis of Diabetic Sensorimotor Polyneuropathy.
作者： Xin Chen , Jim Graham , Ioannis N. Petropoulos , Georgios Ponirakis , Omar Asghar
关键词:
摘要: Objective: Corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, is a noninvasive and objective biomarker for identifying small nerve fiber damage. We have evaluated the diagnostic performance of previously established CCM parameters to novel automated measure corneal complexity called fractal dimension (ACNFrD). Methods: A total 176 subjects (84 controls 92 patients with type 1 diabetes) without diabetic sensorimotor polyneuropathy (DSPN) underwent CCM. Fractal analysis was performed on images using purpose-built software, compared manual measurements. Results: Manual subbasal density (CNFD) (P < 0.0001), length (CNFL) branch (CNBD) 0.05), ACNFrD 0.0001) were significantly reduced DSPN DSPN. The areas under receiver operating characteristic curves comparable: 0.77 CNFD, 0.74 CNFL, 0.69 CNBD, ACNFrD. Conclusions: shows comparable efficiency identify
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