PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity

作者: Y. Kamei , H. Ohizumi , Y. Fujitani , T. Nemoto , T. Tanaka

DOI: 10.1073/PNAS.2135217100

关键词:

摘要: A well balanced body energy budget controlled by limitation of calorie uptake and/or increment expenditure, which is typically achieved proper physical exercise, most effective against obesity and diabetes mellitus. Recently, peroxisome proliferator-activated receptor (PPAR) γ, a member the nuclear receptor, its cofactors have been shown to be involved in lipid metabolism control expenditure. Here we show that PPARγ coactivator 1 (PGC-1) β functions as ERRL1 (for ERR ligand 1), can bind activate orphan ERRs (estrogen receptor-related receptors) vitro. Consistently, PGC-1β/ERRL1 transgenic mice exhibit increased expression medium-chain acyl CoA dehydrogenase, known target pivotal enzyme mitochondrial β-oxidation skeletal muscle. As result, state similar an athlete; namely, are hyperphagic elevated expenditure resistant induced high-fat diet or genetic abnormality. These results demonstrate function protein ERR, level contributes balance vivo, provide strategy for developing novel antiobesity drugs.

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