Comparing different analysis methods for quantifying the MRI amide proton transfer (APT) effect in hyperacute stroke patients

摘要: Amide proton transfer (APT) imaging is a pH mapping method based on the chemical exchange saturation phenomenon that has potential for penumbra identification following stroke. The majority of literature thus far focused generating pH-weighted contrast using magnetization ratio asymmetry analysis instead quantitative mapping. In this study, widely used and model-based were both assessed APT data collected from healthy subjects (n = 2) hyperacute stroke patients 6, median time after onset 2 hours 59 minutes). It was found approach able to quantify effect with lowest variation in grey white matter (≤ 13.8 %) smallest average between these two tissue types (3.48 volunteers. also performed quantitatively better than other measures patient data, where quantified infarct core consistently lower contralateral normal appearing all recruited, group being 1.5 ± 0.3 % (infarct core) 1.9 0.4 (contralateral). Based fitted parameters previously published amide rate relationship, maps generated, first time, imaging.