6-Gingerol relieves myocardial ischaemia/reperfusion injury by regulating lncRNA H19/miR-143/ATG7 signaling axis-mediated autophagy.
作者： Xiang-Wei Lv , Guo-Wei Qin , Pan Lu , Qiu-Yu Qin , Meng-Jie Wang
DOI: 10.1038/S41374-021-00575-9
关键词:
摘要: Myocardial ischemia/reperfusion injury (MIRI) causes severe damage in cardiac tissue, thereby resulting in a high rate of mortality. 6-Gingerol (6-G) is reported to play an essential role in alleviating MIRI. However, the underlying mechanism remains obscure. This study was intended to explore the potential mechanism by which 6-G functions. Q-PCR was employed to quantify the relative RNA levels of long noncoding RNA (lncRNA) H19 (H19), miR-143, and ATG7, an enzyme essential for autophagy, in HL-1 cells. Western blotting …
nature.com
sci-hub.st 参考文章(27)
Paul Z. Gerczuk, Robert A. Kloner, An Update on Cardioprotection Journal of the American College of Cardiology. ,vol. 59, pp. 969- 978 ,(2012) , 10.1016/J.JACC.2011.07.054
Noboru Mizushima, Tamotsu Yoshimori, Beth Levine, Methods in Mammalian Autophagy Research Cell. ,vol. 140, pp. 313- 326 ,(2010) , 10.1016/J.CELL.2010.01.028
Derek J. Hausenloy, Derek M. Yellon, Myocardial ischemia-reperfusion injury: a neglected therapeutic target Journal of Clinical Investigation. ,vol. 123, pp. 92- 100 ,(2013) , 10.1172/JCI62874
Andrew Keniry, David Oxley, Paul Monnier, Michael Kyba, Luisa Dandolo, Guillaume Smits, Wolf Reik, The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r Nature Cell Biology. ,vol. 14, pp. 659- 665 ,(2012) , 10.1038/NCB2521
Ellen C Keeley, Judith A Boura, Cindy L Grines, Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction : A quantitative review of 23 randomised trials The Lancet. ,vol. 361, pp. 13- 20 ,(2003) , 10.1016/S0140-6736(03)12113-7
Anamaria Necsulea, Magali Soumillon, Maria Warnefors, Angélica Liechti, Tasman Daish, Ulrich Zeller, Julie C. Baker, Frank Grützner, Henrik Kaessmann, The evolution of lncRNA repertoires and expression patterns in tetrapods Nature. ,vol. 505, pp. 635- 640 ,(2014) , 10.1038/NATURE12943
Dariush Mozaffarian, Emelia J Benjamin, Alan S Go, Donna K Arnett, Michael J Blaha, Mary Cushman, Sandeep R Das, Sarah De Ferranti, Jean-Pierre Després, Heather J Fullerton, Virginia J Howard, Mark D Huffman, Carmen R Isasi, Monik C Jiménez, Suzanne E Judd, Brett M Kissela, Judith H Lichtman, Lynda D Lisabeth, Simin Liu, Rachel H Mackey, David J Magid, Darren K McGuire, Emile R Mohler III, Claudia S Moy, Paul Muntner, Michael E Mussolino, Khurram Nasir, Robert W Neumar, Graham Nichol, Latha Palaniappan, Dilip K Pandey, Mathew J Reeves, Carlos J Rodriguez, Wayne Rosamond, Paul D Sorlie, Joel Stein, Amytis Towfighi, Tanya N Turan, Salim S Virani, Daniel Woo, Robert W Yeh, Melanie B Turner, None, Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association Circulation. ,vol. 133, ,(2016) , 10.1161/CIR.0000000000000350
Xiaojuan Liu, Chao Zhang, Chi Zhang, Jingjing Li, Wanwan Guo, Daliang Yan, Chen Yang, Jianhua Zhao, Tian Xia, Yuqing Wang, Rong Xu, Xiang Wu, Jiahai Shi, Heat shock protein 70 inhibits cardiomyocyte necroptosis through repressing autophagy in myocardial ischemia/reperfusion injury In Vitro Cellular & Developmental Biology - Animal. ,vol. 52, pp. 690- 698 ,(2016) , 10.1007/S11626-016-0039-8
Tao Fan, Lei Chen, Zhixin Huang, Wei Wang, Boyou Zhang, Yao Xu, Zhangfan Mao, Hao Hu, Qing Geng, Autophagy Activation by Rapamycin Before Hypoxia-Reoxygenation Reduces Endoplasmic Reticulum Stress in Alveolar Epithelial Cells. Cellular Physiology and Biochemistry. ,vol. 41, pp. 79- 90 ,(2017) , 10.1159/000455953
Margherita Neri, Irene Riezzo, Natascha Pascale, Cristoforo Pomara, Emanuela Turillazzi, Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists. Mediators of Inflammation. ,vol. 2017, pp. 7018393- 7018393 ,(2017) , 10.1155/2017/7018393