MicroRNA-372 is associated with poor prognosis in colorectal cancer.

摘要: Objective: MicroRNA-372 (miR-372) is reportedly shown to be an oncogene in human testicular germ cell tumors and gastric cancers, but its expression colorectal cancer (CRC) not yet determined. This study investigated the clinical significance of miR-372 CRC. Methods: qRT-PCR was used evaluate 144 CRC patients, large tumor suppressor 2 (LATS2) also examined as likely target gene miR-372. In vitroassays were performed biological function Results: Multivariate analysis indicated that high independent prognostic factor (p = 0.006). High associated with synchronous liver metastasis 0.035). We found inverse relationship between LATS2 by 0.007) immunohistochemistry 0.042) using tissue samples. Furthermore, pre-miR-372 led a decrease protein increase proliferative activity LoVo cells. significant association low 0.042). Conclusions: suggested novel Our data suggest may serve one genes tissues.