The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung.

摘要: Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients. However, it now recognised that diverse microbial community exists airways comprising aerobic and anaerobic bacteria as well fungi viruses. This rich soup microorganisms provides ample opportunity for interspecies interactions, particularly when considering secreted compounds. Here, we discuss how P. aeruginosa-secreted products can have community-wide effects, with potential to ultimately shape dynamics within lung. We focus on three well-studied traits associated worsening clinical outcome CF: phenazines, siderophores biofilm formation, secretions interactions between other commonly encountered members lung microbiome: Staphylococcus aureus, Burkholderia cepacia complex, Candida albicans Aspergillus fumigatus. These may evolutionary trajectory while providing new opportunities therapeutic exploitation CF microbiome.