Prolactin stimulates food intake in the absence of ovarian progesterone.

摘要: Increases in serum estrogen inhibit food intake. Conversely, progesterone stimulates intake, probably via its antiestrogenic action. We have reported that elevated prolactin also intake female rats. It is unclear whether this effect mediated through levels of progesterone. The present study investigated the effects on and brown fat activity absence Female Osborne-Mendel rats were assigned to one six groups: sham operated (Sham, n = 10), ovariectomized (OVX, OVX + low (EL, 11), EL (PIT, 9), high (EH, EH PIT (n 8). Estrogen by Silastic implants. Prolactin pituitary transplants placed under kidney capsule. Nine days postsurgery, was significantly higher vs. Sham Estrogen-treated (OVX EH) had suppressed values compared with both animals. Finally, hyperprolactinemic PIT) ate more than did estrogen-treated without explants. Despite hyperphagia, no significant differences GDP binding observed. These data indicate ovarian