GlaxoSmithKline Adjuvant Systems in vaccines: concepts, achievements and perspectives
作者： Nathalie Garçon , Patrick Chomez , Marcelle Van Mechelen
关键词:
摘要: The need for potentiating immune responses to recombinant or subunit antigens has prompted GlaxoSmithKline (GSK) Biologicals develop various Adjuvant Systems the design of prophylactic and therapeutic vaccines. are formulations classical adjuvants mixed with immunomodulators, specifically adapted antigen target population. They can activate appropriate innate system subsequently impact on adaptive responses. AS04 is an System that demonstrated significant achievements in several vaccines against viral diseases. AS02, another System, being evaluated contexts, where a strong T-cell response needed afford protection. Likewise, AS01 been developed induction yet stronger T-cell-mediated required. Altogether, promising clinical results strongly support concept allow further development new vaccines, best population mechanisms
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