Asymmetric allylic alkylation by palladium-bisphosphinites
作者： Rakesh K. Sharma , Munirathnam Nethaji , Ashoka G. Samuelson
DOI: 10.1016/J.TETASY.2008.02.015
关键词:
摘要: A series of new chiral palladium-bisphosphinite complexes have been prepared from readily available, naturally occurring alcohols. The were used to efficiently carry out catalytic allylic alkylation 1,3-diphenylpropene-2-yl acetate with dimethyl malonate. based on derivatives ascorbic acid enantioselective alkylations, one which showed an ee as high 97%. Based the structural characterization, it can be surmised that strategic placement phenyl groups is key higher enantioselectivities.
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