Direct estimation of evoked hemoglobin changes by multimodality fusion imaging

摘要: In the last two decades, both diffuse optical tomography DOT and blood oxygen level dependent BOLD-based functional magnetic resonance imaging fMRI methods have been developed as noninvasive tools for evoked cerebral hemodynamic changes in studies of brain activity. Although these technologies measure contrast from similar physiological sources, i.e., hemoglobin levels, modalities are based on distinct physi- cal biophysical principles leading to limitations strengths each method. this work, we describe a unified linear model combine complimentary spatial, temporal, spectro- scopic resolutions concurrently measured signals. Using numerical simulations, demonstrate that con- current BOLD measurements can be used create cross- calibrated estimates absolute micromolar deoxyhemoglobin changes. We apply new analysis tool experimental data ac- quired simultaneously with during motor task, ability more robustly estimate hemo- globin comparison alone, show how approach provide cross-calibrated multimodal method, calibration 3 tesla signal 0.55% ±0.40% change per deoxyhemoglobin.