The Differential Effects of a Selective Kappa-Opioid Receptor Agonist, U50488, in Guinea Pig Heart Tissues
作者： Chi-Feng Hung , Hsin-Ju Li , Hsun-Hao Chang , Gon-Ann Lee , Ming Jai Su
DOI: 10.1155/2015/906039
关键词:
摘要: The differential effects of a selective kappa- (κ-) opioid receptor agonist, U50488, were elucidated by monitoring the contraction isolated guinea pig atrial and ventricular muscles. In electrically driven left atria, U50488 in nanomolar concentration range decreased contractile force. Norbinaltorphimine (norBNI), κ-receptor antagonist, pertussis toxin (PTX) abolished negative inotropic effect U50488. contrast, inhibitory was not affected pretreatment atropine or propranolol. Even though exerted atrium, it did affect force right atrium ventricles paced at 2 Hz. Similarly, beating rate spontaneously also unaffected These results indicate that activation κ-opioid receptors can only produce atria via PTX-sensitive G protein pigs. absence suggests there may be greater distribution functional than ventricles, species-specific.
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core.ac.uk 参考文章(34)
R Eckert, J Utz, W Trautwein, Inhibition of L-type calcium currents in guinea pig ventricular myocytes by the kappa-opioid agonist U50488H does not involve binding to opiate receptors. Journal of Pharmacology and Experimental Therapeutics. ,vol. 274, pp. 627- 633 ,(1995)
Mai Chen, Jing‐Jun Zhou, Kenneth Wan‐Lung Kam, Jian‐Song Qi, Wing‐Yi Yan, Song Wu, Tak‐Ming Wong, None, Roles of KATP channels in delayed cardioprotection and intracellular Ca2+ in the rat heart as revealed by κ‐opioid receptor stimulation with U50,488H British Journal of Pharmacology. ,vol. 140, pp. 750- 758 ,(2003) , 10.1038/SJ.BJP.0705475
Piotr Sobanski, Malgorzata Krajnik, Mohammed Shaqura, Elzbieta Bloch-Boguslawska, Michael Schäfer, Shaaban A. Mousa, The presence of mu-, delta-, and kappa-opioid receptors in human heart tissue Heart and Vessels. ,vol. 29, pp. 855- 863 ,(2014) , 10.1007/S00380-013-0456-5
Lars O. Karlsson, Niklas Bergh, Lizhen Li, Erik Bissessar, Irina Bobrova, Garrett J. Gross, Levent M. Akyürek, Lars Grip, Dose-dependent cardioprotection of enkephalin analogue Eribis peptide 94 and cardiac expression of opioid receptors in a porcine model of ischaemia and reperfusion European Journal of Pharmacology. ,vol. 674, pp. 378- 383 ,(2012) , 10.1016/J.EJPHAR.2011.11.012
W. A. Macdonald, O. B. Nielsen, T. Clausen, Effects of calcitonin gene-related peptide on rat soleus muscle excitability: mechanisms and physiological significance American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 295, ,(2008) , 10.1152/AJPREGU.00893.2007
Craig Bolte, Gilbert Newman, Jo El J. Schultz, Kappa and delta opioid receptor signaling is augmented in the failing heart. Journal of Molecular and Cellular Cardiology. ,vol. 47, pp. 493- 503 ,(2009) , 10.1016/J.YJMCC.2009.06.016
Marc Michael Theisen, Silke Schlottmann, Christian August, Christine Herzog, Gregor Theilmeier, Matthias Maas, Jonas Martin Blumenstiel, Thomas Peter Weber, Hugo Karel Van Aken, Kristoffer Tim Kaerlein, Detection and distribution of opioid peptide receptors in porcine myocardial tissue. Pharmacological Research. ,vol. 84, pp. 45- 49 ,(2014) , 10.1016/J.PHRS.2014.04.008
Jian-Zhong Sheng, Tak-Ming Wong, Chronic U50,488H abolishes inositol 1,4,5-trisphosphate and intracellular Ca2+ elevations evoked by κ-opioid receptor in rat myocytes European Journal of Pharmacology. ,vol. 307, pp. 323- 329 ,(1996) , 10.1016/0014-2999(96)00280-4
Dongman Chao, Ying Xia, Ionic storm in hypoxic/ischemic stress: can opioid receptors subside it? Progress in Neurobiology. ,vol. 90, pp. 439- 470 ,(2010) , 10.1016/J.PNEUROBIO.2009.12.007
Anikó Kovács, László G. Hársing, Gábor Szénási, Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery European Journal of Pharmacology. ,vol. 689, pp. 160- 164 ,(2012) , 10.1016/J.EJPHAR.2012.05.031