Educational weight loss interventions in obese and overweight adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.

摘要: Aim The worldwide prevalence of type 2 diabetes mellitus is increasing, with most individuals the disease being overweight or obese. Weight loss can reduce disease‐related morbidity and mortality weight losses 10–15 kg have been shown to reverse diabetes. This review aimed determine effectiveness community‐based educational interventions for in diabetes. Methods This a systematic meta‐analysis randomized controlled trials (RCT) obese adults, aged 18–75 years, diagnosis Primary outcomes were and/or BMI. CINAHL, MEDLINE, Embase, Scopus Cochrane Central Register Controlled Trials (CENTRAL) searched from inception June 2019. classified into specified priori comparisons according intervention type. A pooled standardized mean difference (SMD) (from baseline follow‐up) 95% confidence intervals (95% CI) between trial groups (difference‐in‐difference) estimated through random‐effects meta‐analyses using inverse variance method. Heterogeneity was quantified I2 publication bias explored visually funnel plots. Results Some 7383 records screened; 228 full‐text articles assessed 49 RCTs (n = 12 461 participants) included this review, 44 suitable inclusion meta‐analysis. Pooled estimates education combined low‐calorie, low‐carbohydrate meal replacements (SMD –2.48, CI –3.59, –1.49, 98%) diets –1.25, –2.11, –0.39, 95%) low‐fat –1.15, 95%CI –2.05, –1.09, 85%) appeared effective. Conclusion Low‐calorie, appear promising achieve largest BMI reductions people