Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales

摘要: Collagen type I is a widely used natural biomaterial that has found utility in variety of biological and medical applications. Its well-characterized structure role as an extracellular matrix protein make it highly relevant material for controlling cell function mimicking tissue properties. abundant number tissues, can be isolated purified protein. This review focuses on hydrogel biomaterials made by reconstituting collagen from solubilized form, with emphasis vitro studies which controlled. The hierarchical the nanoscale to macroscale described, how related across scales. Methods into materials are presented, including molding macroscopic constructs, creation microscale modules electrospinning fibers. modification achieve desired structures functions also addressed, particular mechanical control structure, composite crosslinking collagenous matrices. Biomaterials scientists have remarkable progress rationally designing collagen-based applying them both study biology therapeutic benefit. broad illustrates recent examples techniques thereby direct its functions.