Generating Skeletal Diversity from the C19‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

摘要: The development of new drugs calls for large collections diverse molecules with considerable complexity. Ring distortion natural products provides an efficient and facile approach to access architectures intriguing biological activities, by harnessing their inherent In this study, such a strategy has been explored on abundant C19 -diterpenoid alkaloid, deltaline, enabling the synthesis 32 derivatives bearing broad spectrum unique scaffolds. Extensive spectroscopic studies including X-ray crystallographic analyses strongly supported structures obtained novel skeletons, which present comparable opportunities great contributions made nature discovery lead compounds.