The Effect of Ketamine on Intracranial and Cerebral Perfusion Pressure and Health Outcomes: A Systematic Review

摘要: Study objective We synthesize the available evidence on effect of ketamine intracranial and cerebral perfusion pressures, neurologic outcomes, ICU length stay, mortality. Methods developed a systematic search strategy applied it to 6 electronic reference databases. completed gray literature searched medical journals as well bibliographies relevant articles. included randomized nonrandomized prospective studies that compared with another intravenous sedative in intubated patients reported at least 1 outcome interest. Two authors independently performed title, abstract, full-text reviews, abstracted data from all studies, using standardized forms. Data controlled trials were synthesized qualitative manner because study designs, patient populations, follow-up periods heterogeneous. used Jadad score Cochrane Risk Bias tool assess quality. Results retrieved 4,896 titles, which 10 met our inclusion criteria, reporting 953 patients. One was deemed low risk bias quality assessment domains. All others high domain. 8 small reductions pressure within minutes administration, and 2 studies an increase. None significant differences pressure, or Conclusion According literature, use critically ill does not appear adversely affect patient outcomes.