Phylogenomic analysis of the 2019-nCoV coronavirus
作者： Carmine Ceraolo , Federico M. Giorgi
DOI: 10.1101/2020.02.02.931162
关键词:
摘要: There is rising global concern for the recently emerged novel Coronavirus (2019-nCov). Full genomic sequences have been released by worldwide scientific community in last few weeks order to understand evolutionary origin and molecular characteristics of this virus. Taking advantage all information currently available, we constructed a phylogenetic tree including also representatives other coronaviridae, such as Bat coronavirus (BCoV) SARS. We identified specific BCoV genomes which appear be closest relative new virus, with protein sequence identity 91.1%, providing further evidence zoonotic 2019-nCoV. detected low variability within available 2019-nCoV specimens sequenced so far, despite hyper-variable hotspots. Finally, perform full proteomic comparison identifying key aminoacidic differences model anti-viral strategies on.
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