Dehydrooligopeptides. I. The Facile Coupling of α-Amino Acids with α-Dehydroamino Acids to Dehydrodipeptides
作者： Yasuchika Yonezawa , Chung-gi Shin , Yuji Ono , Juji Yoshimura
DOI: 10.1246/BCSJ.53.2905
关键词:
摘要: N-Cbz- or N-Tos-α-dehydroamino acid (DHA) and its ester were prepared by the condensation of 2-oxo carboxylic with benzyl carbamate p-toluenesulfonamide. Subsequently, N-protected DHA N-free thus obtained coupled several L-α-amino esters (Boc Cbz)-L-α-amino respectively usual peptide synthetic methods to give a number different types dehydrodipeptide. The configurations all new dehydrodipeptides shown have (Z)-geometry.
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