USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair.
作者： Xia Ting , Lu Xia , Jianguo Yang , Lin He , Wenzhe Si
DOI: 10.1093/NAR/GKZ726
关键词:
摘要: How chromatin dynamics is regulated to ensure efficient DNA repair remains be understood. Here, we report that the ubiquitin-specific protease USP11 acts as a histone deubiquitinase catalyze H2AK119 and H2BK120 deubiquitination. We showed physically associated with remodeling NuRD complex functionally involved in process. demonstrated USP11-mediated deubiquitination NuRD-associated deacetylation coordinate allow timely termination of reorganization structure. As such, condensation, genomic stability, cell survival. Together, these observations indicate modifier critically damage response maintenance stability.
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