Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes.

摘要: The etiology of adolescent idiopathic scoliosis is undetermined despite years research. A number hypotheses have been postulated to explain its development, including growth abnormalities. irregular expression hormone and insulin-like factor-1 (IGF-1) may disturb metabolism, result in a gross asymmetry, promote the progress scoliosis. Initial association studies complex diseases demonstrated power candidate gene association. Prior our study, 1 study this field had negative result. replicable vital for reliability. To determine relationship receptor IGF-1 genes with scoliosis, population-based was performed. Single nucleotide polymorphisms potential function were selected from distribution analysis conclusion made confirming insufficiency an between single-nucleotide polymorphism Han Chinese.