Anti-adhesins of Streptococcus sobrinus.

摘要: Several members of the genus Streptococcus seem to be able elaborate surface lectins. The oral streptococci have been reported bind sialic acid ( S. sanguis) and α-glucans (Gibbons Fitzgerald 1969). organisms capable binding include cricetus sobrinus. A few highly cariogenic mutans also can complex with glucans. Most are interacting via lectin-independent sites (Robyt, 1995; Mooser, 1992). In interactions, glucan synthases (dextransucrases or glucosyltransferases, GTFs) use glucans as acceptors for chain extension. glucan-binding on these enzymes distinct from catalytic acting sucrose, sole natural substrate (Mooser, 1992; Mooser Wong, 1988; Robyt, 1982).). presence adhere colonize enamel surfaces leading dental decay. Adhesion is a first step caries. There numerous studies in past decades describing adhesion mechanisms streptococci. If suitable anti-adhesins were available, it follows that bacterial colonization could prevented. several factors which modify microbial adhesion, including antibodies, lysozyme, salivary amylase, proteins (statherin proline-rich proteins, PRPs), resident microbiota producing proteases glycosidases. Some above named promote whereas others inhibit streptococcal enamel. this paper, results presented show an anti-adhesin sobrinus, periodate-oxidized α-1,6 glucan, potent anti-caries agent. not only inhibits lectin (GBL) activities, but inhibitor GTFs.