Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives
作者： Ellen Gleeson , Janease Graham , Sandro Spiller , Irina Vetter , Richard Lewis
DOI: 10.3390/MD13042030
关键词:
摘要: A set of fluorophenoxyanilides, designed to be simplified analogues previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. or Cav2.2 is validated target the treatment refractory chronic pain. Despite being significantly less complex than originally up seven-fold improvement activity was observed.
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