Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation.
作者： C DINARELLO
DOI: 10.1016/J.COPH.2004.03.010
关键词:
摘要: All biological agents currently used for reducing TNFalpha activity in disease are neutralization strategies; however, there several strategies interleukin (IL)-1 activities: the IL-1 receptor antagonist (IL-1Ra), anti-IL-1beta monoclonal antibodies, Trap, type I antibodies to accessory chain and inhibitors of IL-1beta-converting enzyme, now termed caspase-1. In fact, caspase-1 first orally active that target cytokines, as these prevent processing release forms IL-1beta IL-18, which is a member family. The Trap new concept using soluble cytokine receptors bind neutralize specific cytokine. takes advantage high affinity two signaling chains cell surface linked by Fc portion IgG1. IL-1Ra approved treat rheumatoid arthritis; over 75 000 patients, has provided insights into role local systemic inflammation, well safety long-term reduction activity.
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sci-hub.se 参考文章(47)
Hal M. Hoffman, Simon G. Gregory, James L. Mueller, Mark Tresierras, David H. Broide, Alan A. Wanderer, Richard D. Kolodner, Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P Human Genetics. ,vol. 112, pp. 209- 216 ,(2003) , 10.1007/S00439-002-0860-X
R Schindler, J Mancilla, S Endres, R Ghorbani, SC Clark, CA Dinarello, Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood. ,vol. 75, pp. 40- 47 ,(1990) , 10.1182/BLOOD.V75.1.40.40
J Crown, A Jakubowski, N Kemeny, M Gordon, C Gasparetto, G Wong, C Sheridan, G Toner, B Meisenberg, J Botet, A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer Blood. ,vol. 78, pp. 1420- 1427 ,(1991) , 10.1182/BLOOD.V78.6.1420.1420
Giamila Fantuzzi, Adrian J. Puren, Matthew W. Harding, David J. Livingston, Charles A. Dinarello, Interleukin-18 Regulation of Interferon γ Production and Cell Proliferation as Shown in Interleukin-1β–Converting Enzyme (Caspase-1)-Deficient Mice Blood. ,vol. 91, pp. 2118- 2125 ,(1998) , 10.1182/BLOOD.V91.6.2118
CA Dinarello, Biologic basis for interleukin-1 in disease Blood. ,vol. 87, pp. 2095- 2147 ,(1996) , 10.1182/BLOOD.V87.6.2095.BLOODJOURNAL8762095
Hal M. Hoffman, James L. Mueller, David H. Broide, Alan A. Wanderer, Richard D. Kolodner, Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nature Genetics. ,vol. 29, pp. 301- 305 ,(2001) , 10.1038/NG756
L.A. Tartaglia, D. Pennica, D.V. Goeddel, Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. Journal of Biological Chemistry. ,vol. 268, pp. 18542- 18548 ,(1993) , 10.1016/S0021-9258(17)46661-0
M Malyak, W P Arend, J E Sims, M F Smith, S K Dower, T D Whisenand, J G Giri, J L Slack, Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. Journal of Immunology. ,vol. 153, pp. 4766- 4774 ,(1994)
John Crown, Ann Jakubowski, Janice Gabrilove, Interleukin-1: biological effects in human hematopoiesis. Leukemia & Lymphoma. ,vol. 9, pp. 433- 440 ,(1993) , 10.3109/10428199309145750
Lesley Probert, David Plows, George Kontogeorgos, George Kollias, The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice European Journal of Immunology. ,vol. 25, pp. 1794- 1797 ,(1995) , 10.1002/EJI.1830250647