IL-1β, but not IL-1α, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses

摘要: As IL-1 expression is augmented in delayed-type hypersensitivity (DTH) responses, we analyzed the role of this response. DTH responses against methyl BSA (mBSA) were significantly suppressed IL-1b-deficient (IL-1b � /� ) and IL-1a/b mice, but not IL-1a mice. In contrast, IL-1R antagonist (IL-1Ra mice exacerbated. Lymph node cells derived from mBSA-sensitized IL-1b ,I L-1a/b type I (IL-1RI) exhibited reduced proliferative mBSA, while these IL-1Ra demonstrated responses. wild-type following adoptive transfer CD4 1 T also reduced, those given IL-Ra increased. IL-1RI , upon transplantation The recall response mBSA decreased co-culture with dendritic (DCs) normal DCs tumor necrosis factor a (TNF suppressed; magnitude suppression TNF however, was similar to that observed These observations indicate possesses dual functions during necessary for efficient priming cells. addition, cell-derived plays an important activation elicitation phase, resulting production TNF, activate allergen-specific