Post-translational modifications of cellular proteins by polyamines and polyamine-derivatives.

作者: Mauro Piacentini , Maria Paola Ceru’-Argento , Maria Grazia Farrace , Francesco Autuori

DOI: 10.1007/978-1-4684-9042-8_15

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摘要: The aliphatic polyamines putrescine, spermidine and spermine are contituents of all living organisms. Prokaryotes eukaryotes able to synthesize putrescine spermidine, while is confined nucleated cells (1–4). physiological role these amines not completely understood, although many studies have clarified their metabolism some relevant aspects regulation Polyamine synthesis often precedes that DNA, RNA proteins indicating possible involvement in the events (2). In fact enzyme activities polyamine biosynthesis catabolism amine concentration were found vary rapidly proliferating tissues during cellular differentiation both vivo vitro

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