Clinical Utility of Human Papillomavirus Genotyping in Cervical Cancer Screening: A Systematic Review.

摘要: Objective Thirteen human papillomavirus (HPV) genotypes are associated with the highest risk of cervical disease/cancer; however, disease progression and cancer is genotype dependent. The objective this systematic review was to examine evidence for high-grade intraepithelial neoplasia (≥CIN 3) discrimination using HPV genotyping. Materials methods A English non-English articles through MEDLINE, Cochrane, clinicaltrials.gov, abstracts presented at relevant professional society conferences were searched from 2000 2019. Search terms included: screening, genotyping, CIN, persistence, humans, colposcopy; prospective, controlled trials, observational studies, retrospective studies residual specimens; included genotyping (beyond 16/18/45) results. Data obtained independently by authors predefined fields. Risk bias evaluated a modified Newcastle-Ottawa Scale. Grading Recommendations, Assessment, Development Evaluation methodology facilitated overall quality evaluation estimation. study protocol registered PROSPERO International Prospective Register Systematic Reviews (CRD42018091093). primary outcome CIN 3 or worse both baseline different follow-up periods. Results Of 236 identified sources, 60 full texts retrieved 16 articles/sources included. deemed low; negative lesions malignancies low-grade squamous cytology assessed as moderate; that atypical cells-undetermined significance "all cytology" high. Clinical methodological heterogeneity precluded meta-analysis. Human discriminated clinically significant degree, regardless result. Conclusions supports clinical utility in during screening.